Abstract:

Exosomes are microvesicles that contain proteins, lipids and RNAs. Exosomes are  secreted into the extracellular environment,which play an important role in cell-cell communication, immune regulation and maintenance of homeostasis.Exosomes are involved in occurrence and development of eye diseases such as glaucoma, age-related macular degeneration and corneal diseases. By detecting differentially expressed exosomes in aqueous humor, it is possible to find a potential biomarker for early diagnosis of glaucoma and retinal diseases. In addition, exosomes as intercellular communication mediators,  not only participate in the communication between transplanted cells and host cells, but also be used for targeting drug delivery, which has significant clinical importance for the treatment of human corneal transplantation and retinal diseases.(Int Rev Ophthalmol, 2018, 42:   388-392)